01 - In a large bowl, combine buttermilk and hot sauce. Add chicken, turning to coat. Cover and refrigerate for at least 2 hours, or overnight for best flavor.
02 - Preheat oven to 425°F (220°C). In a large bowl, whisk flour, baking powder, baking soda, and salt. Add cold butter and cut in using a pastry blender or fingers until mixture resembles coarse crumbs. Stir in buttermilk just until dough comes together.
03 - Turn dough out onto a floured surface. Gently pat to 1-inch thickness. Cut into rounds using a biscuit cutter. Place on a parchment-lined baking sheet. Brush tops with extra buttermilk. Bake 12–15 minutes, until golden.
04 - In a shallow dish, mix flour, paprika, cayenne, garlic powder, onion powder, oregano, thyme, salt, and black pepper.
05 - Remove chicken from marinade, letting excess drip off. Dredge each piece in seasoned flour, pressing to adhere. Place on a wire rack and let rest 10 minutes.
06 - Heat 2 inches of vegetable oil in a large, heavy skillet to 350°F (175°C). Fry chicken in batches, turning occasionally, until golden brown and cooked through (internal temp 165°F/74°C), about 15–18 minutes. Drain on a wire rack or paper towels.
07 - Arrange fried chicken and warm biscuits on a platter. Serve immediately.